MeScore CRCMedial Colorectal Cancer Score (MeScore CRC) is a software solution that performs algorithm-based analysis of demographic information and lab results and provides personal scores to indicate individuals with higher probability of harboring colorectal cancer compared to the general population.
MeScore CRC is intended to be used by healthcare organizations and healthcare professionals to aid in identifying individuals, age 40 and above, of the general population who are at increased risk of harboring CRC for whom further evaluation is recommended.
MeScore CRC is intended to support healthcare professionals in decision-making and is not intended as a screening or stand-alone diagnostic tool. It is not intended to rule-out or to be used to waive screening or further diagnosis.
The Compliance Challenge
MeScore CRC Technology
MeScore performs batch processing of input files which contain individuals' blood count test results and basic demographic data (gender and age). For the calculation of the score, the model requires, at minimum, gender, year of birth and at least one blood count test.
Potential Benefits of MeScore CRC
MeScore CRC was developed using data from 466,107 Israelis (Maccabi Health Care Services, MHS) and externally validated on an additional 139,205 Israelis (MHS) and 24,985 primary care patients from the UK's Health Information Network (THIN) database.
The performance of the score was evaluated in relation to CRC (according to cancer registry information) using the standard area under the receiver operator curve (AUC), and obtained a value of about 0.82 for the MHS validation. Similar results were achieved on the UK population, demonstrating AUC of 0.81.
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